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It is also possible that the allosteric deformation of the receptor increases affinity for an agonist, resulting in an allosteric synergism. Functional antagonism. Two agonists affect the same parameter (e. g. , bronchial diameter) via different receptors in the opposite direction (epinephrine dilation; histamine constriction).
Members of this class include ?-lactam antibiotics such as the penicillins and cephalosporins, in addition to bacitracin and vancomycin. Penicillins (A). The parent substance of this group is penicillin G (benzylpenicillin). It is obtained from cultures of mold fungi, originally from Penicillium notatum. |
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